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Transforming Cancer Care

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Breast Cancer Research

XENERA-1: a randomised double-blind Phase II trial of xentuzumab in combination with everolimus and exemestane versus everolimus and exemestane in patients with hormone receptor-positive/HER2-negative metastatic breast cancer and non-visceral disease

Journal of Clinical Oncology

First-in-Human, Phase I Dose-Escalation and Dose-Expansion Study of Trophoblast Cell-Surface Antigen 2-Directed Antibody-Drug Conjugate Datopotamab Deruxtecan in Non-Small-Cell Lung Cancer: TROPION-PanTumor01

Nature Medicine

Camonsertib in DNA damage response-deficient advanced solid tumors: phase 1 trial results

Cancer Treatment Reviews

Novel endocrine therapies: What is next in estrogen receptor positive, HER2 negative breast cancer?

Investigational New Drugs

A dose escalation/expansion study evaluating dose, safety, and efficacy of the novel tyrosine kinase inhibitor surufatinib, which inhibits VEGFR 1, 2, & 3, FGFR 1, and CSF1R, in US patients with neuroendocrine tumors

Journal of Clinical Oncology

Tarlatamab, a first-in-class DLL3-targeted bispecific T cell engager, in recurrent small-cell lung cancer: an open-label, phase 1 study

Nature

In situ tumour arrays reveal early environmental control of cancer immunity